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Buy Bosentas.
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Bosentas Structure
- 62.5 mg - Bosentan;
- 125 mg - Bosentan.
Bosentas Indications
Bosentan is indicated for the treatment of pulmonary arterial hypertension (WHO Group I) in patients with WHO Class III or
IV symptoms, to improve exercise ability and decrease the rate of clinical worsening.
Bosentas Dosage
Bosentan treatment should be initiated at a dose of 62.5 mg for 4 weeks and then increased to the maintenance dose of 125 mg.
Doses above 125 mg did not appear to confer additional benefit sufficient to offset the increased risk of liver injury.
Tablets should be administered morning and evening with or without food.
Treatment should be stopped and re-introduction of bosentan should not be considered. There is no experience with re-introduction of bosentan in these circumstances.
If bosentan is re-introduced Bosentan should be at the starting dose; aminotransferase levels should be checked within 3 days and thereafter according to the recommendations above.
Bosentas Contraindications
- Hypersensitivity: Bosentan is also contraindicated in patients who are hypersensitive to Bosentan or any component of the medication.
- Glyburide: An increased risk of liver enzyme elevations was observed in patients receiving glyburide concomitantly with Bosentan. Therefore co-administration of glyburide and bosentan is contraindicated.
- Cyclosporine A: Co-administration of cyclosporine A and Bosentan resulted in markedly increased plasma concentrations of Bosentan. Therefore, concomitant use of bosentan and cyclosporine A is contraindicated.
Bosentas Form
Blister pack of 10 tablets
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